As a pharmaceutical start-up, Locus needed a state-of-the-art environment to produce their products. Because their process involves virulent infective bacteria, the typical start-up approach of leasing space through a Contract Manufacturing Organization (CMO) quickly proved not to be an option. Locus needed to rapidly and efficiently design and build their own facility to produce a truly unique product. This upﬁt transformed a 30-year old, one-story shell space into a cutting-edge BSL-2 laboratory and biomanufacturing space. This project provided for the build-out of 12,000 sf of additional space adjacent to their existing suite to provide for clinical trial production, dispensing, and locker rooms. Additional scope included material air locks, personnel air locks, quarantine spaces, and support spaces. The project was built with maximum flexibility in mind to allow for process changes and potential future expansions. The small footprint unidirectional space flow paired with its industry-leading biopharma equipment provides a state-of-the-art facility to support a potential game-changing therapy with limitless disease fighting potential.